Published Human Studies

List of Published Human Studies of Morinda, Inc. Product & Ingredients

 

 

TNJ, Extra and Max

 

  1. Safety clinical trial
  • Conducted by the British Industrial Biological Research Association (BIBRA).
  • Published in Pacific Health Dialog and the Journal of Food Science
  • 96 people, double-blind, placebo-controlled, one month trial, high dose of 750 ml/day (¾ bottle)
  • TNJ was found to be absolutely safe & reduced number of illness related events
  • Summary Report URL: http://www.ncbi.nlm.nih.gov/pubmed/20443518
  1. Health Benefits in heavy smokers
  • Antioxidant
    1. Conducted by the University of Illinois College of Medicine and TNI R&D
    2. Published in Chemistry Central Journal
    3. 285 people, double-blind, placebo-controlled, one month trial
    4. As little as 1 serving TNJ per day (30 mL or 1 oz) lowered free radicals significantly (fruit juice placebo had no significant effect)
    5. Report URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765950/?tool=pubmed
  • DNA protection- aromatic DNA adducts in heavy smokers
    1. Conducted by the University of Illinois College of Medicine
    2. Published in the journal, Nutrition and Cancer
    3. 203 people, double-blind, placebo-controlled, one month trial
    4. As little as 1 serving TNJ per day (30 mL or 1 oz) lowered amount of DNA damage by approximately half
    5. Report URL: http://www.ncbi.nlm.nih.gov/pubmed/19838937?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
  • Cholesterol & triglyceride lowering- in heavy smokers
    1. Conducted by the University of Illinois College of Medicine
    2. 132 people , double-blind, placebo-controlled, one month trial
    3. Drinking TNJ significantly reduced cholesterol levels, triglycerides, and hs-CRP. TNJ also decreased LDL and homocysteine, but increased HDL.  Placebo had no effect
    4. Report URL: http://www.hindawi.com/journals/tswj/2012/594657/
  • DNA protection- lipid peroxide derived DNA adducts in heavy smokers
    1. Conducted by University of Illinois College of Medicine
    2. 245 people, double-blind, placebo-controlled, one month trial
    3. TNJ reduced the amount of lipid peroxide caused DNA damage 44.6–57.4%.
    4. −Report URL: http://onlinelibrary.wiley.com/doi/10.1002/fsn3.21/pdf
  1. Joint health of the neck (cervical spondylosis)
    • Conducted by the University of Lagos College of Medicine
    • Published in Nigerian Journal of Health and Biomedical Sciences
    • 90 people, therapeutic control groups, one month trial
    • 1 serving of TNJ alone improved range of movement & pain; combination of TNJ & standard therapy had further increased benefits
    • Report URL: http://www.ajol.info/viewarticle.php?id=29710
  2. Energy/Endurance
    • Conducted by the Moscow Scientific and Practical Center of Sports Medicine
    • Published in Journal of Medicinal Plants Research
    • 40 people, placebo-controlled, three week trial
    • TNJ increased endurance by 21% and increased antioxidant activity by 25%. Placebo (blackberry juice) had no effect
    • Report URL: http://www.academicjournals.org/jmpr/PDF/pdf2008/July/Palu%20et%20al.pdf
  3. Immune boosting & antioxidant
    • Conducted by Tianjin Medical University
    • Published in the journal, Chinese Medical Research & Clinical
    • 12 people , two month pilot study
    • TNJ increased adaptive immune system activity by 32% and innate immune system activity by 30%. TNJ decreased oxidative stress in the body by 19%.
    • Summary report URL (article in Chinese): http://www.chemdrug.com/databases/7_18_glcaiekpsgjlptto.html
  4. Drug screen test
  5. Hypertension trial
    • Conducted by Brigham Young University Hawaii
    • Published in American Chemical Society Symposia Series No. 993, Functional Food and Health
    • 10 people, one month open label trial
    • 4 oz. TNJ per day significantly decreased blood pressure, especially systolic blood pressure
    • Report URL: http://pubs.acs.org/doi/abs/10.1021/bk-2008-0993.ch039
  6. Menopause
    • Conducted by the University of Illinois College of Medicine
    • Published in The Journal of Alternative & Complimentary Medicine
    • 8 post-menopausal women , placebo-controlled, three month pilot study
    • TNJ increased improved mood and energy, attenuated hearing loss, and showed evidence of potential anti-osteoporosis effect
    • Report URL: http://www.liebertonline.com/doi/abs/10.1089%2Facm.2004.10.737
  7. Cholesterol—non-smoker
    • Conducted by Brigham Young University Hawaii
    • 10 people, one month pilot study
    • Already healthy cholesterol values remained within healthy normal range
    • TNJ has mild cholesterol lowering & HDL raising potential in non-smokers within the high end range of normal. This displays adaptogenic activity.
    • Available online at http://www.japsonline.com/admin/php/uploads/626_pdf.pdf
  • Conducted by University of Illinois at Chicago, College of Medicine at Rockford
  • Open label three-month intervention trial with 82 osteoarthritis patients.
  • Dose was 3 oz. of TNJ per day
  • Significant improvements in symptoms, such as pain and mobility, were observed, as well as improvements in quality of life factors. Clinical laboratory tests revealed a large margin of safety.
  • Publication of the full paper is in process
  • The registration for this clinical trial is found online at http://www.clinicaltrials.gov/ct2/show/NCT01070264?term=noni&rank=2
  • Publication citation—Wang MY, et al. Morinda citrifolia L. (noni) improves the Quality of Life (QoL) in adults with Osteoarthritis  Functional Foods in Health and Disease 2011, Volume 2 (February 20, 2011).
  • Available online at http://www.functionalfoodscenter.net/files/43301924.pdf .
  1. Effect of TNJ on maximal oxygen uptake (VO2) max in cyclists
    • Conducted at the University of Chile
    • 30 volunteers, three groups (TNJ, placebo, & reference groups)
    • Two weeks TNJ or placebo supplementation for two weeks
    • TNJ group had increased VO2 max and 50 Watt VO
    • Available online at http://www.maxwellsci.com/print/crjbs/v5-177-181.pdf
  2. Effect of TNJ on energy levles and serum cortisol
    • Conducted at the University of Hamburg
    • Human pilot study demonstrating that consuming TNJ helps to increase cortisol levels temporarily, which may increase resistance to stress and increase physical energy/power.
    • The data is currently published in a University of Hamburg PhD dissertation
    • The dissertation is available online at http://www.sub.uni-hamburg.de/opus/volltexte/2009/4090/pdf/NoniPDF.pdf
  3. Protective effect of TNJ on exercise induced muscle damage and endurance
    • Conducted at the University of Port Harcourt.
    • 60 participants, placebo controlled, 30 day trial
    • TNJ improved endurance in university athletes.
    • TNJ lowered serum creatine kinase levels, indicating protection against exercise induced muscle damage.
    • Available online at http://www.idosi.org/wjss/7(1)12/8.pdf
  4. Effect of TNJ on HbA1c of type 2 diabetic
  5. Effect of TNJ on gingivitis
  6. Anti-AGE trial in overweight adults
    • Conducted at the University of Jakarta
    • 34 people, eight week open-label trial
    • Daily ingestion of Max reduced AGE levels, as measured by the AGE Reader.
    • Published in the International Journal of Food Science (http://www.hindawi.com/journals/ijfs/2014/276950/).
  7. Cross-sectional population study with 3,913 Japanese
    • 3,913 Japanese participants
    • AGE levels measured with AGE reader and daily iridoid intake determined from daily TNJ, Extra, or Max ingestion rates.
    • Data analysis revealed that iridoid intake has a dose-dependent effect on lower AGE scores.
    • Published in the International Journal of Food Science (http://www.hindawi.com/journals/ijfs/2014/276950/).
  8. Max and TNJ anti-AGE and weight loss trial in obese adults

 

Noni leaves

  1. Noni leaf serum protection of skin
    • Clinical trial involving 25 people
    • Noni leaf serum, composed of leaf extracts, protected the skin against ultraviolet (UV) light exposure and reduced erythema (redness & swelling)
    • Published in Journal of Natural Medicines
    • The report URL, as an abstract, is http://www.springerlink.com/content/44122428mlt17404/

 

FIT clinical trial

  1. Open label clinical trial of efficacy of Morinda Bioactives FIT body

 

DEFY clinical trial

  1. Open label clinical trial of efficacy of DEFY skin care regimen

 

Noni Seed oil

  1. Open label clinical trial of the topical safety of noni seed oil
  2. Open label clinical trial of the anti-acne activity of noni seed oil

 

TruAge Sugar Stop

  1. Open label clinical trial of the anti-AGE and weight loss activity of Sugar Stop
    • Eleven week open-label trial with 30 adults, where AGE scores declined significantly
    • The change in AGE scores corresponded to an average decrease of 8.83 AGE-associated years
    • Participants also experienced significant declines in weight and fat mass
    • The paper reporting trial results is currently in press and will be available online in July via links at http://www.maxwellsci.com/jp/j2p.php?jid=AJFST.

 

 

 

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